Total synthesis of (+)-grandiamide D, dasyclamide and gigantamide A from a Baylis–Hillman adduct: A unified biomimetic approach

• Andivelu Ilangovan and
• Shanmugasundar Saravanakumar

Beilstein J. Org. Chem. 2014, 10, 127–133, doi:10.3762/bjoc.10.9

• Andivelu Ilangovan Shanmugasundar Saravanakumar School of Chemistry, Bharathidasan University, Tiruchirappalli, 620024, India Syngene International Ltd., Bangalore, 560 099, India 10.3762/bjoc.10.9 Abstract A unified strategy was followed for the synthesis of three putrescine bisamides

• ; dasyclamide; gigantamide A; (+)-grandiamide D; natural products; putrescine bisamides; Introduction Putrescine bisamides are one of the important naturally occurring polyamine alkaloids found in open chain and cyclic forms. The genera Aglaia are the richest source of putrescine bisamides. The cyclic 2

• bisamides such as odorine, dehydroodorine and odorinol exhibited cytotoxic and antiviral activity [5]. There is only a limited number of putrescine bisamides isolated from natural sources and the amount of synthetic approaches known for these structurally interesting and biologically important molecules is